Research Areas‎ > ‎

Aortic valve stenosis

Diastolic function plays a key role in aortic stenosis the most prevalent valve disease in the Western world (2-4% of the elderly and responsible for nearly 50,000 surgical interventions per year in the European Union). 

Virtually all patients who present themselves for aortic valve replacement surgery have endured long-term afterload, concentric hypertrophic remodelling, fibrosis and myocardial stiffening concurring to diastolic dysfunction. Strict application of current surgical referral guidelines which disregard diastolic dysfunction leads to persisting heart failure in 10% of patients and poor, if any, regression of hypertrophy in many more despite primarily successful aortic valve replacement. 

Patients do not get the utmost benefit out of the procedure because it should have probably been performed earlier. Accordingly, it is our purpose to identify myocardial determinants of an incomplete reverse remodelling after aortic valve replacement as well as to contribute to refine and update the criteria for surgical referral.