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Heart failure with preserved ejection fraction

Heart failure is routinely divided into systolic or reduced ejection fraction and diastolic or preserved ejection fraction heart failure. Due to aging and increasing prevalence of systemic arterial hypertension, obesity and diabetes mellitus the latter accounts for a rising proportion of over 50% of cases which is extremely disturbing because the prognosis is as ominous as that of reduced ejection fraction (over 50% mortality at 5-years), and quite contrarily there are no evidence-based therapeutic strategies directed at preserved ejection fraction heart failure cases. 

Interestingly, asymptomatic diastolic dysfunction is highly prevalent in the community (up to 40 % in adults); therefore the identification of risk factors, its early detection and therapeutic targeting are amongst our priorities.