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Pulmonary hypertension and right ventricular failure

Although for decades the right ventricle and pulmonary circulation were forgotten they increasingly concern the practitioner and researcher communities due to recognition of: 


(1) high lethality of severe and rare forms of arterial pulmonary hypertension,
(2) high prevalence of pulmonary hypertension complicating major cardiovascular and respiratory conditions,
(3) strong prognostic relevance, and
(4) fundamental role in congenital heart disease.Moreover, pulmonary hypertension and right ventricular failure are highly lethal and frequent complications of cardiac surgery and intensive care. 

Despite new drug developments for pulmonary arterial hypertension, the prognosis remains poor and countless patients require lung or combined heart-lung transplant or eventually have a lethal outcome. As for other forms of pulmonary hypertension they remain weakly investigated and there are currently no right ventricular-directed therapies. 

All these issues underlie our past, present and future investment in new therapies and approaches to pulmonary hypertension and right ventricular failure as a major goal.