António de Sousa Barros
Institutional Email: asbarros@med.up.pt
ORCID: 0000-0002-9103-5852
Scopus id: 56130256800

Degrees

• PhD, Université Paris-Saclay, AgroParisTech, December 1999.

Short Bio

Following his PhD in Chemometrics in 1999, A Barros, started his Post-Doc studies in the University of Aveiro, from 2000 to 2002 nurturing the project “Development and implementation of chemometric techniques in spectral and e-nose data.” At the same time, his was appointed as a technical advisor on the European project (ASTEQ- Artificial Sensing Techniques for Evaluating Quality).
In the period from 2003 to 2015 he was Assistant Researcher at the University of Aveiro, at the QOPNA research group, developing and implement frameworks and pipeline data analysis systems for applications in food systems (from 2003 to 2008), then from 2008 to 2013, in metabolomics, mostly focused in pregnancy issues, cancer (lung and renal) and age-related diseases (macular degeneration). At the same time (from 2005-2010) he co-founded a spin-off company (FoodMetric SA) for delivering on-line data analysis services to the industry (food sector). Furthermore, in the period from 2006 to 2014 the scientific endeavor was complemented with teaching activities mostly in data analysis, in the University of Aveiro in the Autonomous Science Health department, along with Master lectures in the department of Chemistry. In 2015, A Barros left the University of Aveiro to pursuit as an independent consultant in data analysis, working for several partners (industrial and academic). As of 2017, he was appointed as invited assistant researcher at the Faculty of Medicine, in the Cardiovascular Research unit.

Research interests

Biostatistics, bioinformatics, machine-learning, predictive modelling.

Selected publications

• I Laíns, D Duarte, AS Barros, AS Martins, J Gil, JB Miller, M Marques, T Mesquita, IK Kim, ML Cachulo, D Vavvas, IM Carreira, JN Murta, R Silva, JW Miller, D Husain, AM Gil, “Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy”, PLoS ONE, 12 (5): e0177749, 2017.
• MS Monteiro, AS Barros, J Pinto, M Carvalho, AS Pires-Luís, R Henrique, C Jerónimo, ML Bastos, AM Gil, PG Pinho “Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma”, Scientific Reports, 37275, 2016.
• J Pinto, AS Barros, MRM Domingues, BJ Goodfellow, E Galhano, C Pita, MC Almeida, IM Carreira, AM Gil, “Following Healthy Pregnancy by NMR Metabolomics of Plasma and Correlation to Urine”, Journal of Proteome Research, 14 (2), 1263-1274, 2015.
• CM Rocha, AS Barros, BJ Goodfellow, IM Carreira, A Gomes, V Sousa, J Bernardo, L Carvalho, AM Gil, IF Duarte, “NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma”, Carcinogenesis, 36 (1), 68-75, 2014.
• CC Loureiro, J Gomes, AS Barros, AM Gil, J Carrola, IF Duarte, Jean Bousquet, Ana Todo Bom, SM Rocha, “Urinary metabolomics changes as a predictive biomarker of exacerbations”, Journal of Allergy and Clinical Immunology, 133, 1, 261-263, 2014.

Projects

• Member: “Age-related macular degeneration – can metabolomic profile distinguish progressors? HMSP-ICJ/0006/2013.
• Member: ASTHMA - Gestão futura da asma apoiada por amostragem não invasiva: contributos para a definição de um meio diagnóstico rápido e não invasivo, PTDC/QUI-QUI/117803/2010.
• PI: “The omics challenge: Application and development of chemometric methods to extract information from biosystems. PTDC/QUI-BIQ/119881/2010.
• Member: "Role of the intestine in promoting the lipogenic effects of fructose", PTDC/SAU-MET/111398/2009.
• Member: “Metabolic profiling and biochemical differentiation of human lung tumors by Nuclear Magnetic Resonance (NMR) method, PTDC/QUI/68017/2006.
• Member: “A Nuclear Magnetic Resonance (NMR) - based metabonomic study of health disorders of fetus and mother during pregnancy: towards biochemical characterization and early diagnostics”, PTDC/QUI/66523/2006.
• Member: “PYLORI L&EPS: Structural Characterization of Lipo- and Exopolysaccharides from Helicobacter pylori - Establishment of the chemical and biochemical basis for the development of vaccines and for the understanding of the adhesion processes”, POCI/QUI/56393/2004.

Prizes

• APDF 2005 Celestino da Costa/Jean Perrin
  APDF/FCT/Embaixada de França (12.2005).
• Associação Portuguesa de Bioindústria, APBIO
  1st prize of the Foodmetric project in the 2nd edition of creation of innovative technological-based companies (2005).