Projects (Concluded)

Accurate tidal volume monitoring to optimize safe non-invasive ventilation settings in patients with SARS-CoV-2

ABSTRACT

SARS-CoV-2 is characterized by severe hypoxia with good lung compliance. Elective invasive ventilation has been preferred over Noninvasive Ventilation (NIV), with a consequent increase of ICU resources. It has been reported that patient anxiety and excessive inspired volume during NIV leads to the development of Patient Self-Inflicted Lung Injury (P-SILI) and NIV failure. Accurate and real time Tidal Volume (TV) monitoring may permit to early detect NIV failure and implement a more secure continuous intravenous anesthetic/sedation plan. Thus, we propose an individualized adjustment of NIV settings with accurate TV feedback to reduce treatment failure.

TIMELINE

18 May 2020 – 18 December 2020

UNIC RESEARCHERS

  • Miguel Gonçalves (Principal Investigator)
  • Adelino Leite Moreira
  • Alysson Roncally Carvalho
  • Roberto Roncon-Albuquerque Jr.

TOTAL BUDGET

30.000,00 €

UNIC BUDGET

30.000,00 €

FUNDING

Fundação para a Ciência e Tecnologia, I. P.






DOCnet - Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine

TIMELINE

May 2016 - September 2020

UNIC RESEARCHERS

  • Adelino Leite-Moreira (Principal Investigator UnIC)
  • André Lourenço
  • António Ferreira
  • Carmen Brás-Silva
  • Inês Falcão-Pires
  • Joana Pimenta
  • José Carlos Areias
  • Júlia Maciel
  • Luis Filipe Macedo
  • Maria Amélia Ferreira
  • Paulo Bettencourt
  • Ricardo Carvalho
  • Roberto Roncon

TOTAL BUDGET

3.818.734,30 €

UNIC BUDGET

1.274.950,24 €

FUNDING

CCDRN (NORTE-01-0145-FEDER-000003)






MINOTAUR “Metabolic Therapy for Managing Diastolic Heart Failure”

TIMELINE

May 2016 – September 2020

UNIC RESEARCHERS

  • Adelino Leite-Moreira (Principal Investigator)
  • André Leite-Moreira
  • André Lourenço
  • Dulce Fontoura
  • Glória Conceição
  • Inês Falcão-Pires
  • João Coelho
  • Nádia Gonçalves
  • Sara Leite

TOTAL BUDGET

150.000,00 €

UNIC BUDGET

150.000,00 €

FUNDING

Fundação para a Ciência e Tecnologia (ERA-CVD/0001/2016)






Myocardial Injury in COVID-19: a Prospective Clinical and Mechanistic Study

ABSTRACT

Myocardial injury is detected in a significant percentage of COVID-19 patients, even in the absence of previous cardiovascular disease. Despite its prognostic relevance, the underlying pathophysiological mechanisms, diagnostic approach and therapeutic management are largely unknown. To address this gap, we will implement a comprehensive clinical, analytical and imaging evaluation of COVID-19 patients admitted to the ICU, together with mechanistic studies using post-mortem myocardial samples.

TIMELINE

15 May 2020 – 14 September 2020

UNIC RESEARCHERS

  • Roberto Roncon-Albuquerque Jr. (Principal Investigator)
  • Adelino Leite Moreira
  • António J. Madureira
  • Francisco Vasques-Nóvoa
  • Carla Basílio
  • Rui J. Cerqueira
  • Mariana Fragão-Marques

TOTAL BUDGET

30.000,00 €

UNIC BUDGET

30.000,00 €

FUNDING

Fundação para a Ciência e Tecnologia, I. P.






NETDIAMOND “NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine”

TIMELINE

December 2016 – February 2020

UNIC RESEARCHERS

  • Adelino Leite-Moreira (Coordinator)
  • André Lourenço
  • António Lobo Ferreira
  • Carmen Brás-Silva
  • Cristina Gavina
  • Inês Falcão-Pires
  • Luís Raposo
  • Nuno Bettencourt
  • Paulo Bettencourt
  • Ricardo Fontes Carvalho
  • Rita Ferreira
  • Pedro Mendes Ferreira
  • Sílvia Diaz
  • Fábio Trindade

TOTAL BUDGET

2.494.249,57 €

UNIC BUDGET

285.444,00 €

FUNDING

Fundação para a Ciência e Tecnologia (SAICTPAC/0047/2015)






RVIVENDO “The transcription factor Hand2 and microRNAs in the development of RV failure”

TIMELINE

July 2016 – January 2020

UNIC RESEARCHERS

  • Paula da Costa Martins (Principal Investigator)
  • Inês Falcão-Pires

TOTAL BUDGET

184.608,00 €

UNIC BUDGET

184.608,00 €

FUNDING

FCT (PTDC/BIM-MEC/4578/2014)






Modulation of myocardial diastolic stiffness by stretch. New physiological mechanism, diagnostic and therapeutic implications in preserved ejection fraction heart failure

TIMELINE

July 2016 – June 2019

UNIC RESEARCHERS

  • André Lourenço (Principal Investigator)
  • Adelino Leite-Moreira
  • André Leite-Moreira
  • Inês Falcão-Pires
  • Marta Tavares Silva
  • Rui Cerqueira
  • Sara Leite

TOTAL BUDGET

184.212,00 €

UNIC BUDGET

184.212,00 €

FUNDING

Fundação para a Ciência e Tecnologia (PTDC/DTP-PIC/4104/2014)






DigitalPatient – Plataforma tecnológica inovadora para a transformação de BigData em conhecimento digital e apoio ao diagnóstico médico

TIMELINE

June 2016 – December 2018

UNIC RESEARCHERS

  • Amândio Rocha Sousa (Principal Investigator)
  • Carla Alexandra Araújo
  • Claudia Moura
  • Elsa Irene Azevedo
  • Fernando Falcão Reis
  • Luís Mendonça
  • João Freitas
  • João Sérgio Neves
  • José Pedro Oliveira Pinto
  • Manuel Alberto Falcão
  • Mariana Pintalhão
  • Marina Dias Neto
  • Marta Ramos Silva
  • Ricardo Ladeiras
  • Ricardo Luís Ferreira
  • Rui João Cerqueira
  • Sílvia Marta Oliveira

TOTAL BUDGET

1.043.742,90€

UNIC BUDGET

1.043.742,90€

FUNDING

CCDRN (NORTE-01-0246-FEDER-000007)






Regurgitação paravalvular aórtica após implantação de válvula aórtica transcateter, como melhorar os resultados?

TIMELINE

July 2013 – June 2017

UNIC RESEARCHERS

  • Alexandra Gonçalves (Principal Investigator)
  • Adelino Leite-Moreira
  • André Lourenço
  • Inês Falcão-Pires

TOTAL BUDGET

400.000,00 €

UNIC BUDGET

400.000,00 €

FUNDING

Fundação Ciência e Tecnologia (HMSP-ICS/0007/2012)






Diastolic heart failure: unravelling novel pathophysiologic mechanisms as potential therapeutic targets

TIMELINE

1 January 2013 – December 2015

UNIC RESEARCHERS

  • Adelino Leite-Moreira (Principal Investigator)
  • André Lourenço
  • Carmen Brás-Silva
  • Daniela Miranda
  • Dulce Fontoura
  • Francisco Nóvoa
  • Inês Falcão-Pires
  • João Filipe Viterbo
  • João Sérgio Neves
  • Mário Jorge Amorim
  • Nádia Gonçalves
  • Paulo Chaves
  • Ricardo Ferreira
  • Roberto Roncon-Albuquerque

TOTAL BUDGET

200.000,00 €

UNIC BUDGET

179.600,00€

FUNDING

Fundação Ciência e Tecnologia (EXCL/BIM-MEC/0055/2012)






MEDIA The metabolic road to diastolic heart failure

TIMELINE

January 2011 – December 2015

UNIC RESEARCHERS

  • Adelino Leite-Moreira (Principal Investigator)
  • Dulce Fontoura
  • Sara Leite

TOTAL BUDGET

- €

UNIC BUDGET

1.083.893,00 €

FUNDING

European Commission H2020 (GA - 261409)






Pathophysiological role and therapeutic potential of urocortin 2 in pulmonary hypertension

TIMELINE

July 2013 – October 2015

UNIC RESEARCHERS

  • Carmen Brás-Silva (Principal Investigator)
  • André Lourenço
  • Cláudia Moura
  • Inês Falcão-Pires
  • Miguel Guerra
  • Rui Cerqueira

TOTAL BUDGET

83.098,00 €

UNIC BUDGET

83.098,00 €

FUNDING

Fundação Ciência e Tecnologia (PTDC/DTP-FTO/0130/2012)






Left ventricular reverse remodelling after overload relief: potential role of microRNAs as biomarkers and therapeutic targets

TIMELINE

May 2013 – September 2015

UNIC RESEARCHERS

  • Inês Falcão Pires (Principal Investigator)
  • Adelino Leite-Moreira
  • Benjamim Marinho
  • Cláudia Moura
  • Cristina Gavina
  • Daniel Gonçalves
  • Daniela Miranda
  • Dulce Fontoura
  • Nádia Gonçalves
  • Patricia Rodrigues
  • Paula da Costa Martins

TOTAL BUDGET

94.012,00 €

UNIC BUDGET

94.012,00 €

FUNDING

Fundação Ciência e Tecnologia (PTDC/BIM-MEC/0998/2012)






Ghrelin implications in ocular angiogenesis. Role in the pathophysiology of diabetic retinopahty

TIMELINE

July 2013 – December 2014

UNIC RESEARCHERS

  • Amândio Dias Sousa (Principal Investigator)
  • Fernando Falcão Reis
  • Glória Conceição
  • Marta Tavares Silva
  • Manuel Falcão

TOTAL BUDGET

42.528,00 €

UNIC BUDGET

42.528,00 €

FUNDING

Fundação Ciência e Tecnologia (EXPL/BIM-MEC/0206/2012)






Role of the ghrelin/obestatin system in the aqueous humor drainage mechanisms. Patophysiologic relevance

TIMELINE

December 2010 – August 2014

UNIC RESEARCHERS

  • Amândio Dias Sousa (Principal Investigator)
  • Fernando Falcão Reis
  • Inês falcão Pires
  • Manuel Falcão
  • Sónia Pinho

TOTAL BUDGET

59.000,00 €

UNIC BUDGET

59.000,00 €

FUNDING

Fundação Ciência e Tecnologia (PTDC/SAU-ORG/110683/2009)






Role of the neuregulin system in pulmonary arterial hypertension - pathophysiological and therapeutic implications

TIMELINE

June 2010 – January 2014

UNIC RESEARCHERS

  • Carmen Brás-Silva (Principal Investigator)
  • Adelino Leite-Moreira
  • André Lourenço
  • Cláudia Moura
  • Sónia Pinho

TOTAL BUDGET

86.952,00 €

UNIC BUDGET

86.952,00 €

FUNDING

Fundação Ciência e Tecnologia (PTDC/SAU-FCF/100442/2008)






Nutritional modulation of inflammation, oxidative stress and apoptosis associated with cardiac cachexia

TIMELINE

March 2011 – August 2013

UNIC RESEARCHERS

  • Roberto Roncon ALbuquerque (Principal Investigator)
  • Adelino Leite-Moreira
  • André Lourenço
  • Francisco Nóvoa
  • José Pedro Pinto
  • Nádia Gonçalves
  • Paulo Chaves
  • Rui Cerqueira

TOTAL BUDGET

64.200,00 €

UNIC BUDGET

64.200,00 €

FUNDING

Fundação Ciência e Tecnologia (PTDC/SAU-MET/116119/2009)